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ID 4373
Name Medium-chain-fatty-acid--CoA ligase
Synonyms Not Available
Gene Name Not Available
Protein Sequence
>Medium-chain-fatty-acid--CoA ligase
MEGERMNAFPSTMMDEELNLWDFLERAAALFGRKEVVSRLHTGEVHRTTYAEVYQRARRL
MGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRLSPKEIAYILNHAED
KVLLFDPNLLPLVEAIRGELKTVQHFVVMDEKAPEGYLAYEEALGEEADPVRVPERAACG
MAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSEKDVVLPVVPMFHVNAWCLPYAA
TLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLALADYLESTGHRLKTLRRLVV
GGSAAPRSLIARFERMGVEVRQGYGLTETSPVVVQNFVKSHLESLSEEEKLTLKAKTGLP
IPLVRLRVADEEGRPVPKDGKALGEVQLKGPWITGGYYGNEEATRSALTPDGFFRTGDIA
VWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQERPLAV
VVPRGEKPTPEELNEHLLKAGFAKWQLPDAYVFAEEIPRTSAGKFLKRALREQYKNYYGG
A
Number of Residues 541
Molecular Weight 59572
Theoretical pI 6.47
GO Classification
Function
catalytic activity
Process
physiological process
metabolism
General Function Involved in catalytic activity
Specific Function Not Available
Pathways Not Available
Reactions Not Available
Pfam Domain Function
Signals None
Transmembrane Regions None
Essentiality Non-Essential
GenBank Protein ID Not Available
UniProtKB ID Q6L8F0 Link_out
UniProtKB Entry Name Q6L8F0_THETH Link_out
PDB ID 1V26 Link_out
PDB File show
3D Structure View 3D Structure
Cellular Location Not Available
Gene Sequence
>1626 bp
ATGGAGGGGGAAAGGATGAACGCGTTCCCAAGCACCATGATGGACGAGGAGCTGAACCTC
TGGGACTTTTTGGAGCGGGCGGCGGCGCTTTTCGGTAGGAAGGAGGTGGTCTCCCGCCTC
CACACCGGGGAGGTCCACCGCACCACCTACGCCGAGGTCTACCAAAGGGCCAGGAGGCTC
ATGGGGGGGCTTAGGGCCCTCGGGGTGGGCGTGGGGGACCGGGTGGCCACCCTGGGCTTC
AACCACTTCCGCCACCTCGAGGCCTACTTCGCCGTCCCCGGCATGGGGGCGGTGCTCCAC
ACCGCCAACCCCCGCCTCTCCCCCAAGGAGATCGCCTACATCCTGAACCACGCCGAGGAC
AAGGTCCTCCTCTTTGACCCCAACCTCCTGCCCCTGGTGGAGGCCATACGGGGCGAGCTC
AAGACGGTGCAGCACTTCGTGGTCATGGACGAGAAGGCCCCGGAGGGCTACCTGGCCTAC
GAGGAGGCCCTGGGGGAGGAGGCGGACCCCGTGCGGGTGCCGGAGCGGGCCGCCTGCGGC
ATGGCCTACACCACGGGGACCACGGGCCTCCCCAAGGGGGTGGTCTACAGCCACCGGGCT
TTGGTCCTCCACTCCCTGGCGGCAAGCCTCGTTGACGGCACCGCCCTCTCGGAGAAGGAC
GTGGTCTTGCCGGTGGTCCCCATGTTCCACGTGAACGCCTGGTGCCTGCCCTACGCCGCC
ACCCTGGTGGGGGCCAAACAGGTCCTGCCCGGGCCCAGGCTGGACCCCGCCTCCCTGGTG
GAGCTCTTTGACGGGGAGGGGGTGACCTTCACCGCCGGGGTGCCCACGGTCTGGCTCGCC
CTGGCGGACTACCTGGAAAGCACGGGCCACCGCCTGAAGACCCTGAGGCGGCTCGTGGTG
GGGGGCTCGGCCGCGCCCAGGAGCCTCATCGCCCGCTTTGAGCGGATGGGCGTGGAGGTG
CGCCAGGGCTACGGCCTCACCGAGACCTCCCCGGTGGTGGTGCAGAACTTCGTAAAAAGC
CACCTGGAGTCCCTCTCCGAGGAGGAGAAGCTCACCCTCAAGGCCAAGACGGGCCTCCCC
ATCCCCCTGGTGCGCCTAAGGGTGGCGGACGAGGAGGGCCGCCCCGTGCCCAAGGACGGG
AAGGCCCTGGGGGAGGTCCAGCTCAAGGGCCCCTGGATCACCGGGGGCTACTACGGAAAC
GAGGAGGCCACGCGGAGCGCCCTCACCCCGGACGGCTTCTTCCGCACCGGGGACATCGCC
GTCTGGGACGAGGAGGGGTACGTTGAGATCAAGGACCGGCTCAAGGACCTGATCAAGTCG
GGCGGGGAGTGGATCTCCAGCGTGGACCTGGAGAACGCCCTCATGGGCCACCCCAAGGTG
AAGGAGGCGGCGGTGGTGGCCATCCCCCACCCCAAGTGGCAGGAGAGGCCCCTGGCGGTG
GTGGTGCCCAGGGGCGAGAAGCCCACCCCGGAGGAGCTGAACGAGCACCTCCTAAAGGCC
GGCTTCGCCAAGTGGCAGCTCCCCGACGCCTACGTCTTCGCGGAGGAGATCCCGAGGACA
TCCGCGGGCAAGTTCCTCAAGCGGGCCTTAAGGGAGCAGTACAAGAACTACTACGGAGGC
GCCTGA
GenBank Gene ID AB126656 Link_out
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
HPRD ID Not Available
IUPHAR ID Not Available
Guide to Pharmacology ID Not Available
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
General References Not Available
Drugs
DrugBank ID Drug Name Drug Type Drug Groups
1 DB04272 Citric Acid small molecule experimental
2 DB08231 MYRISTIC ACID small molecule experimental
3 DB04395 Phosphoaminophosphonic Acid-Adenylate Ester small molecule experimental

Susan G. Komen Starts off U-Turn After Prepared Parenthood Cut-Off


After announcing that it was heading to chop funding for Planned Parenthood's breast screenings, Susan G. Komen for your Heal, a breast cancer basis, nowadays declared that it is switching its funding requirements, indicating it is going to likely resume funding to Planned Parenthood, a sexual overall health organization. The general public outcry concerning alleged reasons for Prepared Parenthood remaining dropped for a grantee by Komen seems to get taken the breast cancer charity by surprise.

Most of the people think Komen stopped granting cash as a result of political stress from donors and a new vice-president, that are pro-life (anti-abortion). Planned Parenthood is pro-choice, and presents abortion as component of its in general sexual wellbeing assistance. On the other hand, Komen's donations have not had everything to try and do with abortions - the grants go in the direction of offering predominantly lower-income ladies with potentially life-saving breast scans (mammographies) and breast checks.

When Planned Parenthood's funding was stopped, most wellbeing professionals and advocacy teams stated the move would have no influence on the quantity of abortions performed, but would seriously impact on usage of breast scans by women from poorer homes.

At this time, within a manifeste assertion, Komen claimed it wishes to apologize to the US general public for its modern choice, which perhaps tainted its popularity being an organization committed to preserving women's lives.

Susan G. Komen Board of Directors and Founder and CEO Nancy G. Brinker wrote:

"The situations of this week happen to be deeply unsettling for our supporters, associates and friends and all of us at Susan G. Komen. We have now been distressed with the presumption which the improvements produced to our funding standards had been executed for political reasons or to precisely penalize Planned Parenthood. They were not.

Our primary want was to meet our fiduciary duty to our donors by not funding grant applications produced by businesses below investigation. We will amend the factors to help make distinct that disqualifying investigations has to be felony and conclusive in naturel and never political. That's what is true and reasonable.

Our only objective for our granting process would be to aid women and households within the combat against breast most cancers. Amending our standards will ensure that politics has no position inside our grant procedure. We will continue on to fund present grants, like all those of Prepared Parenthood, and maintain their eligibility to use for future grants, even though preserving the flexibility of our affiliates to generate funding decisions that meet up with the requires in their communities.

It really is our hope and we feel it's time for everybody concerned to pause, slow down and replicate on how grants can most proficiently and directly be administered with out controversies that hurt the cause of females. We urge all people that has participated on this discussion across the country in excess of the previous few days to help you us move previous this concern. We do not want our mission marred or affected by politics - anyone's politics.

Komen's Board of Directors says it can be nowadays liaising with its community and major supporters in a very shift to refocus the organization's notice on its primary mission - preserving women's lives - and finding again to undertaking the great get the job done. The charity asks most of the people for patience and comprehension as it gathers its Komen affiliate marketers nationwide to greatest establish how you can move forward in the way that thoroughly matches its mission.

The reaction to Prepared Parenthood's drop in funding following Komen announced its severing of ties astonished most people around the country. An attractiveness because of the sexual overall health group has resulted in a few renowned names coming forward. Michael Bloomberg, N.Y. Metropolis Mayor, announced yesterday that he was donating $250,000 to create up to the shortfall.

Planned Parenthood mentioned it raised in excess of $400,000 in 24 several hours.

Bloomberg, who appears to believe Komen's transfer was purely political, reported:

"Politics haven't any put in wellbeing care. Breast most cancers screening saves lives and a huge selection of many girls depend on Planned Parenthood. We should be helping adult females accessibility that care, not inserting boundaries in their way."

Komen's donations to Prepared Parenthood made use of to amount of money to close to $700,000 on a yearly basis prior to funding stopped. Critics of your cut-off say this occurred predominantly due to a fresh main at Komen, Senior Vice president Haren Handel, a conservative.

Pertaining to Komen's modify of route declared these days, Cecil Richards, President from the Planned Parenthood Federation, explained:

"The outpouring of assistance for females wanting lifesaving breast most cancers screening this week is astonishing which is a testomony to our nation's compassion and sincerity.

Throughout the final week, hundreds of thousands spontaneously joined a nationwide conversation about lifesaving breast cancer prevention care and bolstered shared values about use of wellness care for all. This compassionate outcry in assistance of these most in want rose above political, ideological, and cultural divides, and will surely be regarded as certainly one of our nation's superior moments for the duration of a contentious political time. Prepared Parenthood thanks every single and each one who has contributed to elevating the importance of breast most cancers avoidance for therefore many ladies in require.

In the latest weeks, the treasured romantic relationship between the Susan G. Komen for that Treatment Basis and Prepared Parenthood may be challenged, and we're now heartened that we can easily keep on to work in partnership towards our shared dedication to breast wellbeing for your most underserved gals. We are enormously grateful that the Komen Basis has clarified its grantmaking criteria, and we look forward to continuing our partnership with Komen partners, leaders and volunteers. What these earlier handful of days have demonstrated is definitely the deep take care of all Us residents share inside the combat versus cancer, and we honor people that are for the helm of this fight.

Prepared Parenthood has become a dependable partner using the Komen Foundation in early most cancers detection and prevention expert services. In particular, Planned Parenthood assists the Komen Foundation attain susceptible populations - low-income females, African-American girls, and Latinas - particularly in rural areas and underserved communities the place Planned Parenthood wellness centers are their only resource of well being treatment. With Komen Foundation grants, around the previous five years, Prepared Parenthood health centers furnished nearly 170,000 clinical breast examinations and more than 6,400 mammogram referrals. With the outpouring of guidance around the previous week, a lot more adult females in need to have will acquire lifesaving breast most cancers care."

Penned by Christian Nordqvist
Copyright: 2012



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